In Macbeth, arguably Lady Macbeth needs two things: one, to be queen, and two, to make amends for her role in Macbeth's murders. When Lady Macbeth receives Macbeth's letter in Act 1 Scene 5, she is consumed with the thought of being queen and resolves to persuade her husband to do all he can--murder--to make himself king immediately. As the first act continues to unfold, she challenges Macbeth's manhood to push him into wanting to prove himself to her. And her plan works--Macbeth does agree to murder Duncan so that he can become the king, making Lady Macbeth queen of Scotland. But Lady Macbeth is not happy for long, and when she learns that Lady Macduff has been murdered in Macbeth's efforts to wipe out all those who doubt him, she feels guilty because Lady Macduff was truly an innocent in the situation. In Act 5 Scene 1, Lady Macbeth is observed by the doctor and gentlewoman sleepwalking and asking to be washed clean of her guilt. So these are Lady Macbeth's two "needs" in the play.
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